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Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma

Frontiers of Medicine doi: 10.1007/s11684-023-1029-3

Abstract: Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma

Keywords： tumor prognosis molecular     Microbiome subsets determine     center analysis microbiome     transcriptome data    

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Relationship of adrenomedullin expression and microvessel density and prognosis in smooth muscle tumor

JIANG Yuan, TIAN Xuehong, YUAN Jie, JIN Yuemei, TAN Yusong

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 398-400 doi: 10.1007/s11684-007-0077-4

Abstract: investigate the relationship between the expression of adrenomedullin (ADM) and microvessel density (MVD) and prognosisin smooth muscle tumor of uterus.figures in LES (<0.05): the more mitotic figures, the higher levels of the ADM expression and poor prognosisThe ADM is an important angiogenic factor in smooth muscle tumor of uterus.marker in estimating the malignant potency of LE and judging the pro gnosis of LES, and as a novel molecular

Keywords： anticarcinogenic     microvessel density     malignant potency     muscle     uterine leiomyosarcoma    

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Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic

Frontiers of Medicine doi: 10.1007/s11684-023-1050-6

Abstract: predisposition and environmental exposures, and explore recent research advancements in precursor lesions and molecularConclusively, we accentuate the urgent demand for more extensive research to enhance the prognosis for

Keywords： pancreatic cancer     cancer screening     single cell     molecular alterations     precancerous lesion     therapy    

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Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications

Aixiu Qiao,Feng Gu,Xiaojing Guo,Xinmin Zhang,Li Fu

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 33-40 doi: 10.1007/s11684-016-0431-5

Abstract:

Breast cancer is the most common malignant tumor in women, and the incidence of this disease has increasedCancer-associated fibroblasts (CAFs), the most abundant cells in tumor stroma, secrete various activeinvasion, and metastasis of cancer but also serve as biomarkers in the clinical diagnosis, therapy, and prognosis

Keywords： cancer-associated fibroblast     breast cancer     progression     prognosis    

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Tumor Molecular Imaging with Nanoparticles Review

Zhen Cheng,Xuefeng Yan,Xilin Sun,Baozhong Shen,Sanjiv Sam Gambhir

Engineering 2016, Volume 2, Issue 1,   Pages 132-140 doi: 10.1016/J.ENG.2016.01.027

Abstract:

Molecular imaging (MI) can provide not only structural images using traditional imaging techniquesbut also functional and molecular information using many newly emerging imaging techniques.It is expected that multimodality nanoparticles (NPs) can lead to precise assessment of tumor biologyand the tumor microenvironment.

Keywords： Tumor     Molecular imaging     Nanoparticles    

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Caveolin proteins: a molecular insight into disease

Hongli Yin,Tianyi Liu,Ying Zhang,Baofeng Yang

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 397-404 doi: 10.1007/s11684-016-0483-6

Abstract: However, a number of detailed molecular mechanisms remain poorly understood.This article focuses on the relationship between caveolin proteins and human diseases and reviews the molecular

Keywords： caveolin     caveolae     microRNA     disease     signaling pathway     heart     tumor    

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Translational medicine in hepatocellular carcinoma

Qiang Gao, Yinghong Shi, Xiaoying Wang, Jian Zhou, Shuangjian Qiu, Jia Fan

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 122-133 doi: 10.1007/s11684-012-0193-7

Abstract: In the past decade, tremendous progress has been achieved in the molecular stratification of HCCs fordiagnosis, prognosis, and therapeutic decision-making.To date, the molecular classification of HCCs has been carried out through transcriptomic, genetic andAs a typical virus and inflammation-associated cancer, both host immune response and tumor microenvironmentaddition, we examine the potential of immunotherapy and strategies targeting various components of the tumor

Keywords： hepatocellular carcinoma     molecular classification     molecular targeted therapies     tumor microenvironment    

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Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 52-60 doi: 10.1007/s11684-016-0433-3

Abstract:

Hepatocellular carcinoma (HCC) is a lethal liver malignancy worldwide. In this study, we reported that protein phosphatase magnesium-dependent 1δ (PPM1D) was highly expressed in the majority of HCC cases (approximately 59%) and significantly associated with high serum α-fetoprotein (AFP) level (P= 0.044). Kaplan-Meier and Cox regression data indicated that PPM1D overexpression was an independent predictor of HCC-specific overall survival (HR, 2.799; 95% CI, 1.346–5.818, P = 0.006). Overexpressing PPM1D promoted cell viability and invasion, whereas RNA interference-mediated knockdown of PPM1D inhibited proliferation, invasion, and migration of cultured HCC cells. In addition, PPM1D suppression by small interfering RNA decreased the tumorigenicity of HCC cells in vivo. Overall, results suggest that PPM1D is a potential prognostic marker and therapeutic target for HCC.

Keywords： PPM1D     hepatocellular carcinoma     prognosis     target therapy    

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Elevated C-reactive protein levels predict worsening prognosis in Chinese patients with first-onset stroke

Jiangtao YAN, Rutai HUI, Daowen WANG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 30-35 doi: 10.1007/s11684-009-0005-x

Abstract: The role of high sensitivity C-reactive protein (hsCRP) in predicting prognosis after stroke in the AsianWe hypothesized that elevated levels of hsCRP were associated with worsening prognosis after stroke inThese findings indicate that increased hsCRP level is associated with worsening prognosis after stroke

Keywords： C-reactive protein     inflammation     stroke    

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Risk factors of prognosis after acute kidney injury in hospitalized patients

Sasa Nie, Zhe Feng, Lihua Xia, Jiuxu Bai, Fenglin Xiao, Jian Liu, Li Tang, Xiangmei Chen

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 393-402 doi: 10.1007/s11684-017-0532-9

Abstract:

The risk factors, especially laboratory indicators, of prognosis after acute kidney injury (AKI) remainIncreased AKI stage, tumor disease, post-cardiopulmonary resuscitation, and RRT were the risk factors

Keywords： acute kidney injury     risk factors     prognosis    

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Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune    

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Proteins moonlighting in tumor metabolism and epigenetics

Lei Lv, Qunying Lei

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 383-403 doi: 10.1007/s11684-020-0818-1

Abstract: interplay of multiple signaling pathways and restrained by oxygen and nutrient accessibility in the tumorThe signal−moonlighting protein−metabolism axis facilitates the adaptation of tumor cells under varying

Keywords： moonlighting function     tumor metabolism     epigenetics    

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Complex interplay between tumor microenvironment and cancer therapy

Minhong Shen, Yibin Kang

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 426-439 doi: 10.1007/s11684-018-0663-7

Abstract:

Tumor microenvironment (TME) is comprised of cellular and non-cellular components that exist withinand around the tumor mass.Given the importance of TME in tumor progression and therapy resistance, strategies that remodel TME

Keywords： tumor microenvironment     therapy response     treatment resistance    

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Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 699-713 doi: 10.1007/s11684-022-0972-8

Abstract: However, the underlying mechanism of alterations in the tumor microenvironments resulting in CAR-T cellSingle-cell RNA sequencing results were obtained from core needle biopsy tumor samples collected fromM2-subtype macrophages were significantly involved in both in vivo and in vitro anti-tumorImmunosuppressive tumor microenvironments persisted before CAR-T cell therapy, during both cell expansionThus, our findings provided a clinical rationale for targeting tumor microenvironments and reprogramming

Keywords： anti-CD19 chimeric antigen receptor T     immunotherapy     diffuse large B cell lymphoma     tumor microenvironment     tumor-associated macrophage     metabolism    

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Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives

Bingxue Shang, Zhifei Cao, Quansheng Zhou

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 67-78 doi: 10.1007/s11684-012-0176-8

Abstract: Although the current antiangiogenic drugs reduce the density of tumor blood vessels and result in tumor, which fosters tumor cells to become more aggressive and metastatic.on the pioneering work on tumor blood vessels by several other researchers.roles in tumor neovascularization, growth, and metastasis.Therefore, multiple-targeting of vasculogenic tumor cells and genes may improve the efficacy of tumor

Keywords： angiogenesis     vasculogenesis     neovascularization     tumor     vasculature     normalization     traditional Chinese medicine    

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Title Author Date Type Operation

Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma

Journal Article

Relationship of adrenomedullin expression and microvessel density and prognosis in smooth muscle tumor

JIANG Yuan, TIAN Xuehong, YUAN Jie, JIN Yuemei, TAN Yusong

Journal Article

Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic

Journal Article

Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications

Aixiu Qiao,Feng Gu,Xiaojing Guo,Xinmin Zhang,Li Fu

Journal Article

Tumor Molecular Imaging with Nanoparticles

Zhen Cheng,Xuefeng Yan,Xilin Sun,Baozhong Shen,Sanjiv Sam Gambhir

Journal Article

Caveolin proteins: a molecular insight into disease

Hongli Yin,Tianyi Liu,Ying Zhang,Baofeng Yang

Journal Article

Translational medicine in hepatocellular carcinoma

Qiang Gao, Yinghong Shi, Xiaoying Wang, Jian Zhou, Shuangjian Qiu, Jia Fan

Journal Article

Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen

Journal Article

Elevated C-reactive protein levels predict worsening prognosis in Chinese patients with first-onset stroke

Jiangtao YAN, Rutai HUI, Daowen WANG

Journal Article

Risk factors of prognosis after acute kidney injury in hospitalized patients

Sasa Nie, Zhe Feng, Lihua Xia, Jiuxu Bai, Fenglin Xiao, Jian Liu, Li Tang, Xiangmei Chen

Journal Article

Heterogeneity of the tumor immune microenvironment and clinical interventions

Journal Article

Proteins moonlighting in tumor metabolism and epigenetics

Lei Lv, Qunying Lei

Journal Article

Complex interplay between tumor microenvironment and cancer therapy

Minhong Shen, Yibin Kang

Journal Article

Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Journal Article

Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives

Bingxue Shang, Zhifei Cao, Quansheng Zhou

Journal Article